From Asymmetric Stem Cell Division to Tissue Engineering
نویسندگان
چکیده
منابع مشابه
Asymmetric stem cell division: lessons from Drosophila.
Asymmetric cell division is an important and conserved strategy in the generation of cellular diversity during animal development. Many of our insights into the underlying mechanisms of asymmetric cell division have been gained from Drosophila, including the establishment of polarity, orientation of mitotic spindles and segregation of cell fate determinants. Recent studies are also beginning to...
متن کاملPolarity in stem cell division: asymmetric stem cell division in tissue homeostasis.
Many adult stem cells divide asymmetrically to balance self-renewal and differentiation, thereby maintaining tissue homeostasis. Asymmetric stem cell divisions depend on asymmetric cell architecture (i.e., cell polarity) within the cell and/or the cellular environment. In particular, as residents of the tissues they sustain, stem cells are inevitably placed in the context of the tissue architec...
متن کاملMechanisms of Asymmetric Stem Cell Division
Stem cells self-renew but also give rise to daughter cells that are committed to lineage-specific differentiation. To achieve this remarkable task, they can undergo an intrinsically asymmetric cell division whereby they segregate cell fate determinants into only one of the two daughter cells. Alternatively, they can orient their division plane so that only one of the two daughter cells maintain...
متن کاملAsymmetric cell division: from A to Z.
Cell divisions producing two daughter cells that adopt distinct fates are defined as asymmetric. In all organisms, ranging from bacteria to mammals, in which development has been studied extensively, asymmetric cell divisions generate cell diversity. Asymmetric cell divisions can be achieved by either intrinsic or extrinsic mechanisms (Fig. 1). Intrinsic mechanisms involve the preferential segr...
متن کاملAsymmetric stem cell division and pathology: insights from Drosophila stem cell systems.
Adult stem cells maintain many tissues and organs throughout the life of an organism by serving as renewable sources of differentiated cells. While stem cells remain in a relatively undifferentiated state, their daughters can commit to differentiation to acquire distinct cell fates. Therefore, a stem cell's choice between self-renewal and commitment to differentiation is of critical importance ...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2017
ISSN: 0925-4773
DOI: 10.1016/j.mod.2017.04.510